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Healthcare

Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

By Noé Seija Nature

MAP Verified Summary — reported by Nature

Nature, Published online: 30 September 2026; doi:10.1038/s41586-026-11087-1By being restricted to target regions by MLLT1–MLLT3 occupancy, activation-induced deaminase activity is able to avoid most off-target mutagenesis during B cell somatic hypermutation.

This story’s context record documents 7 observable dimensions — Origin, Attribution, Specificity, Timing, Framing, Context Change, and Information Relationships — as part of Media Alert Press’s context-documentation ledger. MAP does not score or rate this content. Read the full original story at Nature →

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